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KMID : 0391419940040010062
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Korean Journal of Lipidology
1994 Volume.4 No. 1 p.62 ~ p.67
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The treatment Effect of Acipimox on the Serum lipoprotein(a)
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안우석
오승준/우정택/김성운/양인명/김진우/김영설/최영길
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Abstract
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It has been well knowen that, the high plasma lipoprotein(a) [LP(a)] level and association of increased incidence of atherosclerotic cardiovascualar disease, especially in the patients less than 60 years of age. This study is attempted to examine
the
treatment effect of acipimox on the serum LP(a) concentration.
Twenty-two patients with serum LP(a) concentration greater than 30mg/dl were treated daily with 750mg of acipimox. LP(a) concentrations and the major lipoprotein classes were measured before and after 3 months of therapy.
Serum LP(a) was decreased in 48% after 3 months therapy of acipimox. Reductions in total cholesterol, triglyceride, LDL-cholesterol were 14.5%, 23%, 16%, respectively, with no change of HDL-cholesterol after 3 months therapy on acipimox. The
absolute
decrease of LP(a) concentration was correlated with the pretreatment levels of LP(a) (r=0.703, p=0.0001). the percentage reduction of LP(a) did not correlate with the triglyceride level (r=0.368, p=0.092) or reduction of LDL-cholesterol(r=-0.23,
p=0.429).
Acipimox may be a useful drug for the reduce the serum levels of LP(a), which is now recognised as a strong independent risk factor for ischemic heart disease.
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KEYWORD
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